Bone Morphogenetic Protein-7 Inhibits EMT-Associated Genes in Breast Cancer
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چکیده
منابع مشابه
Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer.
Bone morphogenetic protein 7 (BMP7) counteracts the physiological epithelial-to-mesenchymal transition (EMT), a process that is indicative of epithelial plasticity. Because EMT is involved in cancer, we investigated whether BMP7 plays a role in breast cancer growth and metastasis. In this study, we show that decreased BMP7 expression in primary breast cancer is significantly associated with the...
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BACKGROUND We recently showed that bone morphogenetic protein 7 (BMP7) is overexpressed in primary breast tumors. Here we explored the clinical significance of BMP7 expression in breast cancer. MATERIALS AND METHODS This study included 483 breast cancer patients with complete clinicopathological information and up to 15 years of follow-up. Samples contained 241 lobular carcinomas, 242 ductal ...
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Environmental and genetic factors interact in the process and treatment of colon cancer, although the underlying mechanisms remain elusive. The aim of the study was to examine the role of whether bone morphogenetic protein 7 (BMP7) is involved in the progression of colon cancer under local intratumoral infiltration lymphocytes. A total of 46 cases of pathologically confirmed specimens were obta...
متن کاملBone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone
Metastatic disease is the major cause of cancer deaths, and recurrent tumors at distant organs are a critical issue. However, how metastatic tumor cells become dormant and how and why tumors recur in target organs are not well understood. In this study, we demonstrate that BMP7 (bone morphogenetic protein 7) secreted from bone stromal cells induces senescence in prostate cancer stem-like cells ...
متن کاملBone morphogenetic protein 7 inhibits tumor growth of human uveal melanoma in vivo.
PURPOSE Bone morphogenetic protein-7 (BMP7), a member of the TGF-beta superfamily, is essential for early ocular morphogenesis, and lack of BMP7 causes epithelial development disturbances in the eye. In the present study, the association of tumorigenicity and malignant behavior of human uveal melanoma with BMP7 expression and the possibility that overexpression of BMP7 in uveal melanoma affects...
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ژورنال
عنوان ژورنال: Cellular Physiology and Biochemistry
سال: 2015
ISSN: 1015-8987,1421-9778
DOI: 10.1159/000430249